Acetaminophen Toxicity Experimental and Clinical Advances

English | 2025 | PDF | 17 MB | 481 Pages

Barry Rumack, Hartmut Jaeschke, Mitchell McGill, 9780443158773, 978-0443158773, 978-0-443-15877-3, 0443158770, 0443158789, 9780443158780, 978-0443158780, B0DNLGR69H

Acetaminophen Toxicity: Experimental and Clinical Advances provides detailed information on the risks of consuming the drug in various situations and effective treatments of toxicity. Divided into two parts, the foundational aspects of this book cover the mechanism of toxicity in a detailed manner beginning with the history of acetaminophen to newly explored areas of genetics, proteomics, and metabolomics. The second half goes on to discuss clinical practices and examine where further research and therapeutic approaches may be headed. This part answers key questions about whom to treat, what are the exceptions, how long do you treat, how much antidote do you need, when are other treatments necessary, and what are those other treatments. With contributions from experts in the field, this book is a thorough, well-researched, and valuable reference for scientists, researchers, and clinicians engaged in pursuing better and more accurate diagnosis and treatment of patients with acetaminophen toxicity.

– Includes comprehensive coverage of fundamental mechanisms of toxicity.
– Provides risk analysis regardless of patient presentation or timing of ingestion or amount with algorithmic support.
– Covers how to determine the level of toxicity and need for liver transplant with algorithmic support.
– Outlines new therapeutic approaches.