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Protein Instability at Interfaces During Drug Product Development

Original price was: د.إ940.00.Current price is: د.إ543.00.

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Description

Pages:
340
Language:
English
Format:
PDF
Size:
6 MB
ISBN-10:
3030571769
ISBN-13:
978-3030571764

(AAPS Advances in the Pharmaceutical Sciences Series, 43) 1st ed. 2021 Edition

by Jinjiang Li (Editor), Mary E. Krause (Editor), Raymond Tu (Editor)

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

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