The History of Alternative Test Methods in Toxicology

د.إ735.00

Colour Matt Finshed

Description

Year:2019
Pages:341
Language:English
Format:PDF
Size:6 MB
ISBN-10:128136979
ISBN-13:978-0128136973
ASIN:B07JN6GXHM

(History of Toxicology and Environmental Health) 1st Edition

by Michael Balls (Editor), Robert Combes (Editor), Andrew Worth (Editor)

The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique.

The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity.

These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies.

The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique.

The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity.

These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.

  • Covers each global region in a systematic fashion, showing how regions compare in terms of problems faced and resolution approaches
  • Includes a thorough chronology of alternatives research, thus providing a complete overview
  • Focuses on methods of direct relevance to humans to address issues of efficacy and waste

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.

78
    78
    Your Cart
    American Indian Health and Nursing
    1 X د.إ20.00 = د.إ20.00
    Alzheimers Disease Diagnosis and Treatment Guide
    1 X د.إ100.00 = د.إ100.00
    Advanced Practice in Endocrinology Nursing
    4 X د.إ40.00 = د.إ160.00
    Clinical Dilemmas in Viral Liver Disease
    1 X د.إ200.00 = د.إ200.00
    Anesthesia for Cardiac Surgery 3rd Edition
    2 X د.إ200.00 = د.إ400.00
    Antibiotic basics for clinicians
    1 X د.إ120.00 = د.إ120.00
    Advanced Practice Palliative Nursing
    1 X د.إ30.00 = د.إ30.00
    Ace Education Chemistry O level
    1 X د.إ433.00 = د.إ433.00
    Edexcel a Level Biology Student Book 1
    2 X د.إ100.00 = د.إ200.00
    Bariatric Robotic Surgery A Comprehensive Guide
    1 X د.إ601.00 = د.إ601.00
    Placeholder
    USMLE Step 1 Pathology Lecture Notes 2024
    1 X د.إ150.00 = د.إ150.00
    Anesthesia in Day Care Surgery
    1 X د.إ120.00 = د.إ120.00
    The Beginner's Guide to Engineering
    1 X د.إ171.00 = د.إ171.00
    Fundamentals of Nuclear Pharmacy 7th Edition
    1 X د.إ20.00 = د.إ20.00
    Microbiology Fundamentals
    1 X د.إ666.00 = د.إ666.00
    Trends in Human Performance Research
    1 X د.إ252.00 = د.إ252.00
    Cell Biology of Herpes Viruses
    1 X د.إ250.00 = د.إ250.00
    Anesthesia in High Risk Patients
    1 X د.إ210.00 = د.إ210.00
    Basic Geriatric Nursing 6th Edition
    1 X د.إ20.00 = د.إ20.00
    A.D.A.M. Student Atlas of Anatomy 2nd Edition
    1 X د.إ164.52 = د.إ164.52
    Rare Lung Diseases
    1 X د.إ852.00 = د.إ852.00
    A Textbook of Community Nursing 2nd Edition
    1 X د.إ20.00 = د.إ20.00
    Advanced Ceramics for Dentistry
    1 X د.إ25.00 = د.إ25.00
    Anesthesia A Comprehensive Review 6th Edition
    1 X د.إ150.00 = د.إ150.00
    Consults in Obstetric Anesthesiology
    1 X د.إ275.00 = د.إ275.00
    Hysteroscopy
    1 X د.إ1,471.00 = د.إ1,471.00
    Anesthesia and the Fetus
    1 X د.إ230.00 = د.إ230.00
    Dr. Carl's Colonoscopy insertion method
    1 X د.إ145.00 = د.إ145.00
    Knowledge Encyclopedia Human Body
    1 X د.إ96.00 = د.إ96.00
    Alzheimers Disease Advances for a New Century
    1 X د.إ150.00 = د.إ150.00
    Asthma An Atlas of Investigation and Diagnosis
    1 X د.إ125.00 = د.إ125.00
    The Fascinating Engineering Book for Kids
    1 X د.إ87.00 = د.إ87.00
    Natural Molecules in Neuroprotection and Neurotoxicity
    1 X د.إ3,528.00 = د.إ3,528.00
    Environmental Endocrine Toxicants
    1 X د.إ654.00 = د.إ654.00

    Add to cart