Sale!

Model-Assisted Bayesian Designs for Dose Finding and Optimization

Original price was: د.إ1,176.00.Current price is: د.إ765.00.

Colour Matt Finished

Description

Pages:
234
Language:
English
Format:
PDF
Size:
9 MB
ISBN-10:
036714624X
ISBN-13:
9780367146245, 9781032357126, 9780429052781, 978-0367146245, 978-1032357126, 978-0429052781, 978-0-367-14624-5, 978-1-032-35712-6, 978-0-429-05278-1

by Ying Yuan (Author), Ruitao Lin (Author), J. Jack Lee (Author)

Bayesian adaptive designs provide a critical approach to improve the efficiency and success of drug development that has been embraced by the US Food and Drug Administration (FDA). This is particularly important for early phase trials as they form the basis for the development and success of subsequent phase II and III trials.

The objective of this book is to describe the state-of-the-art model-assisted designs to facilitate and accelerate the use of novel adaptive designs for early phase clinical trials. Model-assisted designs possess avant-garde features where superiority meets simplicity. Model-assisted designs enjoy exceptional performance comparable to more complicated model-based adaptive designs, yet their decision rules often can be pre-tabulated and included in the protocol―making implementation as simple as conventional algorithm-based designs. An example is the Bayesian optimal interval (BOIN) design, the first dose-finding design to receive the fit-for-purpose designation from the FDA. This designation underscores the regulatory agency’s support of the use of the novel adaptive design to improve drug development.

Features

  • Represents the first book to provide comprehensive coverage of model-assisted designs for various types of dose-finding and optimization clinical trials
  • Describes the up-to-date theory and practice for model-assisted designs
  • Presents many practical challenges, issues, and solutions arising from early-phase clinical trials
  • Illustrates with many real trial applications
  • Offers numerous tips and guidance on designing dose finding and optimization trials
  • Provides step-by-step illustrations of using software to design trials

Written by internationally recognized research leaders who pioneered model-assisted designs from the University of Texas MD Anderson Cancer Center, this book shows how model-assisted designs can greatly improve the efficiency and simplify the design, conduct, and optimization of early-phase dose-finding trials. It should therefore be a very useful practical reference for biostatisticians, clinicians working in clinical trials, and drug regulatory professionals, as well as graduate students of biostatistics. Novel model-assisted designs showcase the new KISS principle: Keep it simple and smart!

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.

77
    77
    Your Cart
    Histopathology Reporting
    1 X د.إ890.00 = د.إ890.00
    Computational Intelligence in Oncology
    1 X د.إ990.00 = د.إ990.00
    Umbilical Cord Blood Banking and Transplantation
    1 X د.إ300.00 = د.إ300.00
    Therapeutic Endoscopic Ultrasound
    1 X د.إ869.00 = د.إ869.00
    Digital Health
    1 X د.إ55.00 = د.إ55.00
    DATA INFORMATICS & TECHNOLOGY
    1 X د.إ1,080.00 = د.إ1,080.00
    Detection Systems in Lung Cancer and Imaging
    1 X د.إ990.00 = د.إ990.00
    CURA TUS DIENTES Y ENCÍAS NATURALMENTE
    2 X د.إ271.00 = د.إ542.00
    Consults in Obstetric Anesthesiology
    1 X د.إ275.00 = د.إ275.00
    A Century of Plant Virology in India
    1 X د.إ250.00 = د.إ250.00
    Essentials of Mental Health
    1 X د.إ550.00 = د.إ550.00
    ABC of Urology 3rd Edition
    2 X د.إ100.00 = د.إ200.00
    Transpathology Molecular Imaging-Based Pathology
    2 X د.إ970.00 = د.إ1,940.00
    Routledge Handbook of Water and Health
    1 X د.إ700.00 = د.إ700.00
    Pictorial Atlas of Neuroradiological Signs
    1 X د.إ1,176.00 = د.إ1,176.00
    Cannabis Physiopathology Epidemiology Detection
    1 X د.إ200.00 = د.إ200.00
    Principles of Drug Therapy in Neurology
    1 X د.إ876.00 = د.إ876.00
    Intelligent Computing Techniques in Biomedical Imaging
    3 X د.إ1,058.00 = د.إ3,174.00
    Edexcel a Level Chemistry Student Book 1
    1 X د.إ100.00 = د.إ100.00
    Ace Education Mathematics O level
    1 X د.إ100.00 = د.إ100.00
    Polymer-Drug Conjugates
    1 X د.إ543.00 = د.إ543.00
    Radiosurgery of the Skull Base A Case-Based Approach
    1 X د.إ1,234.00 = د.إ1,234.00
    Medical Image and Signal Analysis in Brain Research
    1 X د.إ1,693.00 = د.إ1,693.00
    Long-Term Care Facilities
    1 X د.إ660.00 = د.إ660.00
    Computed Tomography for Technologists
    1 X د.إ634.00 = د.إ634.00
    Sacroiliac Joint Techniques
    1 X د.إ646.00 = د.إ646.00
    Anesthesia Informatics
    1 X د.إ150.00 = د.إ150.00
    Anesthesia for Spine Surgery
    1 X د.إ170.00 = د.إ170.00
    Anesthesia in Cosmetic Surgery
    1 X د.إ200.00 = د.إ200.00
    Deep Learning for Medical Image Analysis
    1 X د.إ764.00 = د.إ764.00
    Autoimmune Disease Diagnosis
    1 X د.إ550.00 = د.إ550.00
    Proteomics Mass Spectrometry Methods
    1 X د.إ77.00 = د.إ77.00

    Add to cart