Exploration of Host Genetic Factors Associated with Malaria

Description

Pages:
174
Language:
English
Format:
PDF
Size:
5 MB
ISBN-10:
9813347600
ISBN-13:
978-9813347601
ASIN:
B08YDWV3QW
1st ed. 2021 Edition

by Tabish Qidwai (Author)

This book is aimed to cover the role of genetic polymorphisms in human genes related to RBC disorders, metabolic enzymes, immune response, and cytoadherence in the susceptibility/resistance to malaria caused by Plasmodium falciparum. The chapters provide current information on the balancing trait and the significance of such traits in the malaria resistance. The book covers polymorphisms in the genes of the red blood cells-sickle cell anaemia; glucose-6-phosphate dehydrogenase deficiency and thalassemia that confer protection against malaria. In addition, the book explores selection of genetic variations in the human genome as genetic control mechanism against malaria in endemic regions. It also provides a comprehensive overview of the molecular epidemiology and natural selection of alleles in the genes which are associated with malaria, and presents description of the role of human genetic polymorphisms in malaria disease risk and disease outcome.