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Diversity-Oriented Synthesis

Original price was: د.إ818.00.Current price is: د.إ654.00.

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Description

Pages:
659
Language:
English
Format:
PDF
Size:
21.5 MB
ISBN-10:
9.78112E+12
ISBN-13:
978-1118145654

1st Edition

by Andrea Trabocchi (Author), Stuart L. Schreiber (Foreword)

Discover an enhanced synthetic approach to developing and screening chemical compound libraries 

Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology.

Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book:

  • Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles
  • Expands on the concept of diversity-oriented synthesis by describing chemical libraries
  • Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays
  • Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research

This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications.

Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.

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