Sale!

Bioisosteres in Medicinal Chemistry

Original price was: د.إ938.00.Current price is: د.إ876.00.

Colour Matt Finished

Description

Pages:
242
Language:
English
Format:
PDF
Size:
3 MB
ISBN-10:
3527330151
ISBN-13:
978-3527330157

1st Edition

by Nathan Brown (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.

28
    28
    Your Cart
    Where the Forest Meets the Stars
    1 X د.إ53.00 = د.إ53.00
    Long-Term Care Facilities
    1 X د.إ660.00 = د.إ660.00
    365 Days of Art
    1 X د.إ81.00 = د.إ81.00
    Exosome Communication
    1 X د.إ890.00 = د.إ890.00
    Endoscopic Ultrasonography
    1 X د.إ547.00 = د.إ547.00
    Novel Formulations and Future Trends
    1 X د.إ88.00 = د.إ88.00
    Alzheimers Disease By Alia Bucciarelli
    1 X د.إ100.00 = د.إ100.00
    Innovations in Endoscopic Ear Surgery
    1 X د.إ869.00 = د.إ869.00
    Modern Inference Based on Health-Related Markers
    1 X د.إ880.00 = د.إ880.00
    Ancient Medicine
    1 X د.إ610.00 = د.إ610.00
    Trustworthy AI in Medical Imaging
    1 X د.إ970.00 = د.إ970.00
    Essential Concepts in Toxicology By Gupta P.K
    1 X د.إ4,500.00 = د.إ4,500.00
    10 Minutes a Day Phonics for Ages 3-5
    1 X د.إ41.00 = د.إ41.00
    New Frontiers Extracellular Vesicles
    1 X د.إ400.00 = د.إ400.00
    Drugs in Neurology
    1 X د.إ876.00 = د.إ876.00

    Add to cart