Sale!

Bioisosteres in Medicinal Chemistry

Original price was: د.إ938.00.Current price is: د.إ876.00.

Colour Matt Finished

Description

Pages:
242
Language:
English
Format:
PDF
Size:
3 MB
ISBN-10:
3527330151
ISBN-13:
978-3527330157

1st Edition

by Nathan Brown (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.

36
    36
    Your Cart
    The Silo Series Boxed Set
    1 X د.إ173.00 = د.إ173.00
    Biomechanical Basis Of Human Movement
    1 X د.إ2,050.00 = د.إ2,050.00
    Alzheimers Disease Advances for a New Century
    1 X د.إ150.00 = د.إ150.00
    Clinical Pharmacy and Therapeutics 6th Edition
    1 X د.إ180.00 = د.إ180.00
    The Adult Hip Hip Preservation Surgery
    1 X د.إ891.00 = د.إ891.00
    Find Your Happy
    1 X د.إ59.00 = د.إ59.00
    Pictorial Atlas of Neuroradiological Signs
    1 X د.إ1,176.00 = د.إ1,176.00
    Foundation 3-Book Boxed Set
    1 X د.إ167.00 = د.إ167.00
    Femme et Fitness
    1 X د.إ111.00 = د.إ111.00
    A Comprehensive Approach to Congenital Heart Diseases
    1 X د.إ1,718.00 = د.إ1,718.00
    FOUNDATIONS OF EXERCISE MECHANICS
    1 X د.إ205.00 = د.إ205.00
    WHO Classification of Skin Tumours 4th Edition
    1 X د.إ125.00 = د.إ125.00
    Red Rising
    1 X د.إ106.00 = د.إ106.00
    Anesthesia and the Fetus
    1 X د.إ230.00 = د.إ230.00
    How to Win Friends & Influence People
    1 X د.إ92.00 = د.إ92.00
    Limited Radiography
    1 X د.إ819.00 = د.إ819.00
    Exosome Communication
    1 X د.إ890.00 = د.إ890.00
    Privileged Scaffolds in Drug Discovery
    1 X د.إ1,234.00 = د.إ1,234.00

    Add to cart